Stem cells shed microparticles
Mobilization of stem cells after liver injury takes a few days, which might be too long after severe liver injury. Already a few hours after liver damage, however, small cellular components of stem cells can be detected in the peripheral blood. This is interesting in that these microparticles resemble the cells of origin both in terms of their surface profile and their cellular content. We were able to prove that cells from the bone marrow can in principle modulate other cells, such as endothelial cells, by fusing with them through the release of such microparticles (Cartoon 2). This transfer of distinct cellular information (stem cell-derived mRNA, miRNA, proteins…) through microparticles is extremely important in terms of a better understanding of intercellular communication in liver regeneration and also as a possible therapeutic alternative to cellular therapy.
Ongoing efforts
We are convinced that stem and immune cell therapy can make a hopeful contribution to improving regeneration after injury and increasing the safety of liver resections in humans. We have been able to put together important pieces over the last few years, supported by the generous funding by the Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung and American Liver Fundation. However, a better understanding is urgently needed to bring cellular therapies into the clinic. We are currently choosing translational approaches to confirm results from basic science studies in patients. The primary goal is to identify a therapy that is as efficient, cost-effective and safe as possible. Our efforts are directed towards testing cellular therapy to support liver regeneration in clinical trials in the near future.
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