Schematic experimental set-up: To ensure a continuous observation of the cultures, the SlideReactor is positioned on a microscope, continuously perfused by a roller pump. Probe-heads within the medium reservoir allow continuous determination of relevant process parameters. The perfusion system the microscope and the camera are placed in a heating unit adjusted to 37°C.
Cells cultured in the SlideReactor and the respective controls: Primary human hepatocytes (a,b), WiDr cells (c,d), primary human fibroblasts (e,f) and primary human keratinocytes (g,h). Magnification: 100x (a-d) and 200x (e-h).