Ex vivo machine perfusion: current applications and future directions in liver transplantation
J. Michelotto, J.M.G.V. Gassner, S. Moosburner, V. Muth, M.S. Patel, M. Selzner, J. Pratschke, I.M. Sauer, N. Raschzok
Ex vivo machine perfusion: current applications and future directions in liver transplantation
J. Michelotto, J.M.G.V. Gassner, S. Moosburner, V. Muth, M.S. Patel, M. Selzner, J. Pratschke, I.M. Sauer, N. Raschzok
Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation-A Propensity Score-Matched Analysis
S. Moosburner, I.M. Sauer, F. Förster, T. Winklmann, J.M.G.V. Gassner, P.V. Ritschl, R. Öllinger, J. Pratschke, N. Raschzok
Declined Liver Grafts - Analysis of the German Donor Population from 2010 to 2018
S. Moosburner, N. Raschzok, C. Schleicher, D. Bösebeck, J.M.G.V. Gaßner, P.V. Ritschl, A. Rahmel, I.M. Sauer, J. Pratschke
Dual versus single vessel normothermic ex vivo perfusion of rat liver grafts using metamizole for vasodilatation
F. Claussen, J.M.G.V. Gassner, S. Moosburner, D. Wyrwal, M. Nösser, P. Tang, L. Wegener, J. Pohl, A. Reutzel-Selke, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
The Effects of MELD-Based Liver Allocation on Patient Survival and Waiting List Mortality in a Country with a Low Donation Rate
P.V. Ritschl, L. Wiering, T. Dziodzio, M. Jara, J. Kruppa, U. Schoeneberg, N. Raschzok, F. Butz, B. Globke, P. Seika, M. Maurer, M. Biebl, W. Schöning, M. Schmelzle, I.M. Sauer, F. Tacke, R. Öllinger, J. Pratschke
Hospitalization before liver transplantation predicts post-transplant patient survival - a propensity-score matched analysis
L. Wiering, R. Öllinger, J. Kruppa, U. Schoeneberg, T. Dziodzio, M. Jara, M. Biebl, R. Dargie, N. Raschzok, W. Schöning, D. Eurich, M. Schmelzle, I.M. Sauer, J. Pratschke, P.V. Ritschl
Tissue-based miRNA mapping in alcoholic liver cirrhosis: different profiles in cirrhosis with or without hepatocellular carcinoma
P. Felgendreff, N. Raschzok, K. Kunze, A. Leder, S. Lippert, S. Klunk, H.M. Tautenhahn, H.M. Hau, R.B. Schmuck, A. Reutzel-Selke, I.M. Sauer, M. Bartels, M.H. Morgül
Development of a rat liver machine perfusion system for normothermic and subnormothermic conditions
M. Nösser, J.M.G.V. Gassner, S. Moosburner, D. Wyrwal, F. Claussen, K.H. Hillebrandt, R. Horner, P. Tang, A. Reutzel-Selke, D. Polenz, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
2019
Hepatocyte Transplantation to the Liver via the Splenic Artery in a Juvenile Large Animal Model
J. Siefert, K.H. Hillebrandt, S. Moosburner, P. Podrabsky, D. Geisel, T. Denecke, J.K. Unger, B. Sawitzki, S. Gül-Klein, S. Lippert, P. Tang, A. Reutzel-Selke, M.H. Morgul, A.W. Reske, S. Kafert-Kasting, W. Rüdinger, J. Oetvoes, J. Pratschke, I.M. Sauer, N. Raschzok
Macrosteatosis is a huge problem in liver transplantation – however, not the only one we face
S. Moosburner, I.M. Sauer, J.M.G.V, Gassner, C. Schleicher, D. Bösebeck, A. Rahmel, J. Pratschke, N. Raschzok
Impact of Percoll purification on isolation of primary human hepatocytes
R. Horner, J.G.M.V. Gassner, M. Kluge, P. Tang, S. Lippert, K.H. Hillebrandt, S. Moosburner, A. Reutzel-Selke, J. Pratschke, I.M. Sauer, N. Raschzok
High donor age for liver transplantation : Tackling organ scarcity in Germany
S. Moosburner, P.V. Ritschl, L. Wiering, J.M.G.V. Gassner, R. Öllinger , J. Pratschke, i.M. Sauer, N. Raschzok
Improvement of normothermic ex vivo machine perfusion of rat liver grafts by dialysis and Kupffer Cell inhibition with glycine
J.M.G.V. Gassner, M. Nösser, S. Moosburner, R. Horner, P. Tang, L. Wegener, D. Wyrwal, F. Claussen, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
2018
Prevalence of Steatosis Hepatis in the Eurotransplant Region: Impact on Graft Acceptance Rates
S. Moosburner, J.M.G.V. Gassner, M. Nösser, J. Pohl, D. Wyrwal, F. Claussen, P.V. Ritschl, D. Dragun, J. Pratschke, I.M. Sauer, N. Raschzok
The predictive value of the LiMax-test for the isolation of primary human hepatocytes
R.D. Major, M. Kluge, M. Jara, M. Nösser, R. Horner, J. Gassner, B. Struecker, P. Tang, S. Lippert, A. Reutzel-Selke, D. Geisel, T. Denecke, M. Stockmann, J. Pratschke, I.M. Sauer, N. Raschzok
Plasma expansion is key for sustained liver function and viability during normothermic and subnormothermic ex vivo machine perfusion in a rat model
J.M.G.V. Gassner, M. Nösser, R. Horner, K.H. Hillebrandt, S. Moosburner, L. Wegener, P. Demko, R. Arsenic, B. Struecker, J. Pratschke, I.M. Sauer, N. Raschzok
The magnetic field of magnetic resonance imaging systems does not affect cells labeled with micrometer-sized iron oxide particles
M. Kluge, A. Leder, K.H. Hillebrandt, B. Struecker, D. Geisel, T. Denecke, R.D. Major, A. Reutzel-Selke, P. Tang, S. Lippert, Ch. Schmidt, J. Pratschke, I.M. Sauer, N. Raschzok
Computed tomography-based survey of the vascular anatomy of the juvenile Göttingen minipig
J. Siefert, K.H. Hillebrandt, M. Kluge, D. Geisel, P. Podrabsky, T. Denecke, M. Nösser, J. Gassner, A. Reutzel-Selke, B. Strücker, M.H. Morgul, S. Guel-Klein, J.K. Unger, A. Reske, J. Pratschke, I.M. Sauer, N. Raschzok
Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans
H. Napierala, K. Hillebrandt, N. Haep, P. Tang, M. Tintemann, J. Gassner, M. Noesser, H. Everwien, N. Seiffert, M. Kluge, E. Teegen, D. Polenz, S. Lippert, D. Geisel, A. Reutzel-Selke, N. Raschzok, A. Andreou, J. Pratschke, I.M. Sauer, B. Struecker
The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism
C. von Loeffelholz, S. Lieske, F. Neuschäfer-Rube, D.M. Willmes, N. Raschzok , I.M. Sauer, J. König, M. Fromm, P. Horn, A. Chatzigeorgiou, A. Pathe-Neuschäfer-Rube, J. Jordan, A.F. Pfeiffer, C. Mingrone, S.R. Bornstein, P. Stroehle, C. Harms, F.T. Wunderlich, S.L. Helfand , M. Bernier, R. de Cabo, G.I. Shulman, T. Chavakis, G.P. Püschel, A.L. Birkenfeld
Improved rat liver decellularization by arterial perfusion under oscillating pressure conditions
B. Struecker, A. Butter, K. Hillebrandt, D. Polenz , A. Reutzel-Selke, P. Tang, S. Lippert, A. Leder, S. Rohn, D. Geisel, T. Denecke, K. Aliyev, K. Jöhrens, N. Raschzok, P. Neuhaus, J. Pratschke, I.M. Sauer
2016
Evolution of graft morphology and function after recellularization of decellularized rat livers
A. Butter, K. Aliyev, K.-H. Hillebrandt, N. Raschzok, M. Kluge, N. Seiffert, P. Tang, H. Napierala, M.I. Ashraf, A. Reutzel-Selke, A. Andreou, J. Pratschke, I.M. Sauer, B. Struecker
Hepatocyte isolation after laparoscopic liver resection
R. Horner*, M. Kluge*, R.M. Major, A. Reutzel-Selke, J. Gassner, M. Nösser, B. Strücker, M.H. Morgül, J. Pratschke, I.M. Sauer, N. Raschzok
Allogeneic liver transplantation and subsequent syngeneic hepatocyte transplantation in a rat model – proof of concept for in vivo tissue engineering
S. Rohn, J. Schroeder, H. Riedel, D. Polenz, K. Stanko, A. Reutzel-Selke, P. Tang, L. Brusendorf, N. Raschzok, P. Neuhaus, J. Pratschke, B. Sawitzki, I.M. Sauer, M.T. Mogl
microRNA signatures in peripheral blood fail to detect acute cellular rejection after liver transplantation
N. Raschzok, A. Reutzel-Selke, R. Schmuck, L. Tannus, M. Morgul, C. Dietel, A. Leder, B. Struecker, S. Lippert, H. Sallmon, M. Schmelzle, M. Bartels, S. Jonas, J. Pratschke, I.M. Sauer
Human hepatocyte isolation: Does portal vein embolization affect the outcome?
M. Kluge, A. Reutzel-Selke, H. Napierala, K.H. Hillebrandt, R.D. Major, B. Struecker, A. Leder, J. Siefert, P. Tang, S. Lippert, D. Seehofer, J. Pratschke, I.M. Sauer, N. Raschzok
Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver
C. von Loeffelholz, S. Döcke, J.F. Lock, S. Lieske, P. Horn, J. Kriebel, S. Wahl, P. Singmann, T. de Las Heras Gala, H. Grallert, N. Raschzok, I.M. Sauer, R. Heller, G. Jahreis, R.A. Claus, M. Bauer, M. Stockmann, A.L. Birkenfeld, A.F. Pfeiffer
The impact of directly acting antivirals on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C
N. Raschzok, E. Schott, A. Reutzel-Selke, I. Damrah, S. Gül-Klein, B. Strücker, I.M. Sauer, J. Pratschke, D. Eurich, M. Stockmann
Acute graft dysfunction 17 years after liver transplant: A challenging clinical and histologic manifestation of hepatitis E
K.H. Hillebrandt, R. Arsenic, J. Hofmann, D. Eurich, S. Gül, B. Strücker, I.M. Sauer, J. Pratschke, M. Stockmann, N. Raschzok
2015
microRNAs in liver tissue engineering – new promises for failing organs
N. Raschzok, H. Sallmon, J. Pratschke, I.M. Sauer
Procedure for Decellularization of Rat Livers in an Oscillating-pressure Perfusion Device
K. Hillebrandt, D. Polenz, A. Butter, P. Tang, A. Reutzel-Selke, A. Andreou, H. Napierala, N. Raschzok, J. Pratschke, I.M. Sauer, B. Struecker
CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation
N. Raschzok, A. Reutzel-Selke, R.B. Schmuck, M.H. Morgul, U. Gauger,K.A. Prabowo, L.-M. Tannus, A. Leder, B. Struecker, S. Boas-Knoop, M. Bartels, S. Jonas, Ch. Lojewski, G. Puhl, D. Seehofer, M. Bahra, A. Pascher, J. Pratschke, I.M. Sauer
Micron-sized iron oxide-containing particles for microRNA-targeted manipulation and MRI-based tracking of transplanted cells
A. Leder*, N. Raschzok*, C. Schmidt, D. Arabacioglu, A. Butter, S. Kolano, L.S. de Sousa Lisboa, W. Werner, D. Polenz, A. Reutzel-Selke, J. Pratschke, I.M. Sauer
2014
Liver support strategies: cutting-edge technologies
B. Struecker, N. Raschzok, I.M. Sauer
Independent Effects of Sham Laparotomy and Anesthesia on Hepatic microRNA Expression in Rats
W. Werner, H. Sallmon, A. Leder, S. Lippert, A. Reutzel-Selke, M.H. Morgül, S. Jonas, S. Dame, P. Neuhaus, J. Iacomini, S.G. Tullius, I.M. Sauer, N. Raschzok
2013
Functionalizable silica-based micron-sized iron oxide particles for cellular Magnetic Resonance Imaging
N. Raschzok, C.M. Langer, Ch. Schmidt, K.H. Lerche, N. Billecke, K. Nehls, N.B. Schlüter, A. Leder, S. Rohn, M.T. Mogl, L. Lüdemann, L. Stelter, U.K. Teichgräber, P. Neuhaus, I.M. Sauer
Elevated hepatic chemerin gene expression in progressed human non-alcoholic fatty liver disease
S. Döcke, J.F. Lock, A.L. Birkenfeld, S. Hoppe, S. Lieske, A. Rieger, N. Raschzok, I.M. Sauer, S. Florian, M.A. Osterhoff, R. Heller, K. Herrmann, S. Lindenmüller, P. Horn, M. Bauer, M.O. Weickert, P. Neuhaus, M. Stockmann, M. Möhlig, A.Fh. Pfeiffer C. von Loeffelholz
Evaluation of Arginine deiminase treatment in melanoma xenografts using 18F-FLT PET
S. Döcke, J.F. Lock, A.L. Birkenfeld, S. Hoppe, S. Lieske, A. Rieger, N. Raschzok, I.M. Sauer, S. Florian, M.A. Osterhoff, R. Heller, K. Herrmann, S. Lindenmüller, P. Horn, M. Bauer, M.O. Weickert, P. Neuhaus, M. Stockmann, M. Möhlig, A.Fh. Pfeiffer C. von Loeffelholz
Noninvasive monitoring of liver cell transplantation
N. Raschzok, H.M. Morgül, L. Stelter, I.M. Sauer
2012
Feasibility of fast dynamic MRI for non-invasive monitoring during ectopic liver cell transplantation to the spleen in a porcine model
N. Raschzok, J. Pinkernelle, N. Billecke, K. Nehls, M. Powerski, I.M. Sauer, U. Teichgraber
Liver regeneration after partial hepatectomy: inconsistent results of expression screenings for human, mouse, and rat miRNAs
N. Raschzok, H. Sallmon, C. Dame, I.M. Sauer
An operational concept for long-term cinemicrography of cells in mono- and co-culture under highly controlled conditions - the SlideObserver
N. Billecke, N. Raschzok, S. Rohn, M.H. Morgul, R. Schwartlander, M. Mogl, S. Wollersheim, K.R. Schmitt*, I.M. Sauer*
2011
Temporal expression profiles indicate a primary function for microRNA during the peak of DNA replication after rat partial hepatectomy
N. Raschzok, W. Werner, H. Sallmon, N. Billecke, C. Dame, P. Neuhaus, I.M. Sauer
Labelling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation
N.N. Kammer, N. Billecke, M.H. Morgul, M.K. Adonopoulou, M. Mogl, M.D. Huang, S. Florek, K.R.L. Schmitt, N. Raschzok, I.M. Sauer
CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells
G. Rago, C.M. Langer, C. Brackman, J.P. Day, K.F. Domke, N. Raschzok, C. Schmidt, I.M. Sauer, A. Enejder, M.T. Mogl, M. Bonn
In vitro evaluation of magnetic resonance imaging contrast agents for labeling human liver cells: implications for clinical translation
N. Raschzok, D.A. Muecke, M.K. Adonopoulou, N. Billecke, W. Werner, N.N. Kammer, A. Zielinski, P.A. Behringer, F. Ringel, M.D. Huang, P. Neuhaus, U. Teichgräber, I.M. Sauer
2010
Monitoring of liver cell transplantation in a preclinical swine model using Magnetic Resonance Imaging
N. Raschzok, U. Teichgräber, N. Billecke, A. Zielinski, K. Steinz, N.N. Kammer, M.H. Morgul, S. Schmeisser, M.K. Adonopoulou, L. Morawietz, B. Hiebl, R. Schwartlander, W. Rüdinger, B. Hamm, P. Neuhaus, I.M. Sauer
2009
Quantification of Cell Labelling with Micron-Sized Iron Oxide Particles Using Continuum Source Atomic Absorption Spectrometry
N. Raschzok, N. Billecke, N.N. Kammer, M.H. Morgul, M.K. Adonopoulou, I.M. Sauer, S. Florek, H. Becker-Ross, M.-D. Huang
Sonographically guided placement of intravenous catheters in minipigs
J. Pinkernelle, N. Raschzok, U. Teichgräber
2008
Imaging of Primary Human Hepatocytes Using Micron-Sized Iron Oxide Particles and Clinical Magnetic Resonance Tomography
N. Raschzok*, M.H. Morgul*, J. Pinkernelle, F.W.R. Vondran, N. Billecke, N.N. Kammer, G. Pless, M.K. Adonopoulou, C. Leist, L. Stelter, U. Teichgraber, R. Schwartlander, I.M. Sauer
Tracking of primary human hepatocytes with clinical MRI – initial results with Tat-peptide modified superparamagnetic iron oxide particles
M.H. Morgul*, N.Raschzok*, R. Schwartlander, F.W.R. Vondran, R. Michel, L. Stelter, J. Pinkernelle, A. Jordan, U. Teichgraber, I.M. Sauer
Isolation of primary human hepatocytes after partial hepatectomy – Criteria for identification of the most promising liver specimen
F.W.R.Vondran, E. Katenz, R. Schwartlander, M.H. Morgul, N. Raschzok, X.B.Gong, X.D. Cheng, D. Kehr, I.M. Sauer
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