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ESAO 2012 - Final Program Online!

Prof. Dr. Gustav Steinhoff, congress president of the XXXIX. ESAO Congress, invites you to Rostock on September 26th – 29th, 2012. The venue of the ESAO 2012 congress is the Academy of Music and Theatre, which resides in an old monastery in the city centre.
The motto of the ESAO Congress 2012 will be “from replacement to regeneration – from science to clinic”. The current state of organ assist and organ support allows for a rapidly advancing clinical practice for several hundred thousand patients worldwide.
The scientific program committee did select 59 keynote lectures of renowned international experts, 131 selected oral presentations and 101 poster presentations from worldwide scientific contributors. Nine poster presentations were selected for short oral presentation. We provide a clear program structure by highlighting one special organ system each congress day: heart/cardiovascular (Chair: G. Steinhoff) , liver (Chair: S. Mitzner) and kidney (Chair: W. Ramlow). The program comprises 45 oral and 2 poster sessions with cardiovascular, dialysis, biomaterials and apheresis topics (www.esao2012.org). Above all the congress program integrates aspects of both basic science and clinical development with a clear focus on translation and clinical practice. We intend to host you on an excellent and exciting congress by inviting outstanding experts and by giving young and promising clinicians and scientists the opportunity to present their work. Especially for young scientists there will be one day for yESAO activities (Tuesday, Sept. 25, 2012). Industry symposia, a poster exhibition and an industrial exhibition will complete the congress program.

We are looking forward to seeing you in Rostock 2012.

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Our manuscript "Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants" has been accepted for publication in Frontiers in Immunology, section Alloimmunity and Transplantation. Authors are Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, and Barbara Kern.

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APC), particularly dendritic cells (DC), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DC (cDC) and APC on the immunogenicity of skin and skin-containing VCA grafts, using mouse models of skin and hind limb transplantation.
By post-transplantation day 6, skin grafts demonstrated severe rejections, characterized by predominance of recipient CD4 T cells. In contrast, hind limb grafts showed moderate rejection, primarily infiltrated by CD8 T cells. While donor depletion of cDC and APC reduced frequencies, maturation, and activation of DC in all analysed tissues of skin transplant recipients, reduction in DC activities was only observed in the spleen of hind limb recipients. Donor cDC and APC depletion did not impact all lymphocyte compartments but significantly affected CD8 T cells and activated CD4 T in lymph nodes of skin recipients. Moreover, both donor APC and cDC depletion attenuated the Th17 immune response, evident by significantly reduced Th17 (CD4+IL-17+) cells in the spleen of skin recipients and reduced levels of IL-17E and lymphotoxin-α in the serum samples of both skin and hind limb recipients. In conclusion, our findings underscore the highly immunogenic nature of skin component in VCA. The depletion of donor APC and cDC mitigates the immunogenicity of skin grafts while exerting minimal impact on VCA.

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